![]() Mehregan also described a similar perforating disorder and coined them as “reactive perforating collagenosis.” In 1968, Mehregan described a series of 11 cases of “elastosis perforans serpiginosa” and based on such descriptions, he first proposed the concept of “transepidermal elimination” in 1970. In the subsequent years, many such cases were reported and then in 1958, the term “elastosis perforans serpiginosa” was given for a particular variant of perforating disorder by Dammert and Putkonen. The phenomenon of expulsion of such materials via epidermis was first observed in detail by Freudenthal in 1930 who identified it as amyloid in his own case. ![]() The first case of perforating dermatosis was described by Josef Kyrle in 1916 who termed it as “hyperkeratosis follicularis et parafollicularis in cutem penetrans.” In 1927, Fisher described a patient with circinate papular eruption on neck containing perforating amorphous plugs but he did not elaborate further and considered it as an atypical presentation of what Kyrle had described before. ![]() Elimination of exogenous foreign substances or altered dermal constituents from dermis to the skin surface via epidermal channel is one of the functions of this zone which has been the mainstay in the pathogenesis of various perforating dermatoses. Dermoepidermal junction is the most complex structural and functional microscopic zone of the skin that enables both epidermal and dermal units to interact in many complex ways in order to perform various functions.
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